Which condition is caused by a lack of pancreatic hormone?

Diabetes mellitus is caused by a deficiency in the production of insulin, which is a hormone made by the pancreas. In a healthy body, insulin helps regulate blood sugar levels by facilitating the uptake of glucose into cells, allowing it to be used for energy. When the body cannot produce enough insulin (as seen in type 1 diabetes) or cannot use it effectively (as seen in type 2 diabetes), it leads to high blood sugar levels, which characterizes diabetes mellitus.

The other conditions listed are not directly caused by a lack of a pancreatic hormone. Hyperthyroidism and hypothyroidism are related to thyroid hormone imbalances, while hypoglycemia typically refers to low blood sugar levels, which can occur for various reasons, including over-medication with insulin or other diabetes medications, but it is not a condition caused by a lack of pancreatic hormone itself. Thus, diabetes mellitus is the correct answer as it directly links to the role of insulin produced by the pancreas.